Abstract: Objective To study and evaluate the effect of liquid nitrogen freezing on the treatment of skin lesions in various sites and the adverse reactions. Methods A total of 206 patients with skin tumor treated in our hospital from May, 2015 to May, 2017 were included in the study. The patients were divided into groups according to gender and age. A total of 55 people in 35-50 years of age group. A total of 151 people in 51-72 years old group. Cryotherapy was performed by applying liquid nitrogen with cotton swabs. The therapeutic effect was evaluated by the treatment of the skin loss after treatment. After the treatment, the lesion was observed and the patients were asked to evaluate the adverse effects of liquid nitrogen cryotherapy. Results The data measured by age and sex groups were statistically analyzed. The P value was 0.217 and 0.789, and there was no significant difference (P>0.05). Age and sex are not the key factors that influence the treatment outcome. According to the treatment results, cryotherapy skin tag has good curative effect.The one-time cure rate reached 114 cases, accounting for 55.3%. The total effective rate (including cure, significant and effective therapeutic class three) reached 202 cases, accounting for 98.1%. Adverse reaction results show that the existence of adverse reactions of edema, blisters, bleeding blister, scar and infection after cryosurgery, the higher incidence of edema and blisters, respectively accounting for 69.9% and 63.1%. Conclusion Cryotherapy of skin neoplasm with high cure rate and significant effect, but this method also has certain adverse risks such as edema, blisters and lesions, etc. Observation is needed for the subsequent processing and timely medical treatments. But overall effect and adverse reaction is low. The treatment has the advantages of simple operation as well as low cost, which is worthy of promotion and further research.