Characteristics of automatic dysfunction in pregnant women with gestational hypertension and its clinical significance
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摘要: 目的 探讨妊娠期高血压孕产妇自主神经功能损害特点及临床意义。 方法 前瞻性收集建德市第一人民医院2016年1月-2017年1月收治的妊娠期高血压孕产妇82例作为观察组,同时收集50例健康孕产妇作为对照组。观察2组孕产妇心率变异性,同时分析妊娠期高血压孕产妇心率变异性与妊娠结局的相关性。 结果 与对照组比较,观察组24 h全部窦性R-R间期标准差显著降低[(97.54±9.63) ms vs.(110.92±9.21) ms,P<0.001];每5 min窦性R-R间期均值的标准差显著降低[(101.56±9.47) ms vs.(109.32±9.42) ms,P<0.001];24 h连续5 min窦性R-R间期标准差的均值显著降低[(41.47±8.83) ms vs.(45.82±8.71) ms,P=0.007];所有临近窦性R-R间期差值的均方根显著降低[(27.82±9.23) ms vs.(31.91±9.55) ms,P=0.016];所有相邻2个窦性R-R间期差值大于50 ms的心博数占全部心搏数的百分比显著降低[(10.21±2.38)% vs.(13.38±4.91)%,P<0.001]。观察组孕产妇心率变异性降低程度为正常、轻度、中度和重度的分别为50.00%、39.02%、8.54%和2.44%,对照组分别为80.00%、18.00%、2.00%和0.00%,差异有统计学意义(P=0.006)。亚组分析显示心率变异性降低的妊娠期高血压孕产妇剖宫产率、早产率和孕产妇24 h尿白蛋白含量均显著增加(P<0.05)。 结论 妊娠期高血压孕产妇自主神经功能损害较严重,可导致妊娠结局不良。Abstract: Objective To explore the characteristics of automatic dysfunction in pregnant women with gestational hypertension and its clinical significance. Methods Eighty-two pregnant women with gestational hypertension (observation group) and 50 healthy pregnant women (control group) in our hospital from January, 2016 to January, 2017 were prospectively collected. The heart rate variability of both groups was observed. The correlation between the heart rate variability and pregnancy outcome was studied. Results Compared with the control group, 24 h standard deviation of sinus R-R intervals of the observation group decreased significantly[(97.54 ±9.63) ms vs. 110.92 ±9.21 ms, P<0.001];each 5 min mean standard deviation of sinus R-R interval decreased significantly (101.56 ±9.47 vs. 109.32 ±9.42 ms, P<0.001); 24 h continuous 5 min standard deviation of sinus R-R interval decreased significantly[(41.47 ±8.83) vs. 45.82 ±8.71 ms, P=0.007]; all near the sinus R-R interval difference decreased significantly (27.82 ±9.23 vs.31.91 ±9.55 ms, P=0.016); a percentage of all the number of heart beat the number of all the two adjacent sinus RR interval difference was greater than 50 ms, which decreased significantly (10.21 ±2.38 vs. 13.38 ±4.91, P<0.001). The decrease of heart rate variability of the pregnant women in the observation group was divided into normal, mild, moderate and severe, and the value was 50.00%, 39.02%, 8.54% and 2.44%, respectively, and in the control group was 80.00%, 18.00%, 2.00% and 0.00%, respectively, P=0.006. According to the analyses of sub-group, the cesarean section rate, premature rate and 24-hour urinary albumin content in the gestational hypertension pregnant women with decreased heart rate variability increased significantly (P<0.05). Conclusion The automatic functional impairment in the pregnant women with hypertension is serious, which can lead to poor pregnancy outcome.
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Key words:
- Gestational hypertension /
- Autonomic function /
- Pregnancy outcome
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