Abstract: Objective To analyze the clinical symptoms and lower extremity anterograde venography imaging, to sum up the clinical features of pulmonary embolism complicated with deep venous thrombosis of the lower extremities, and to provide guidance for clinical diagnosis and treatment. Methods The clinical symptoms and anterograde lower extremity venography imaging of 43 cases who were diagnosed as pulmonary embolism at the first Affiliated Hospital of Bengbu Medical College from October, 2013 to October, 2016 were retrospectively analyzed. Results There were 27 patients with lower extremity mild swelling, 10 patients with lower extremity severe swelling, 8 patients without lower extremity swelling in clinical symptoms. The percentages were 60.0%, 28.9% and 11.1%, respectively. The patients of calf deep vein thrombosis with popliteal vein, femoral vein and iliac vein patency was 9 (20% of the total number); the patients of popliteal vein and femoral vein thrombosis with iliac vein patency was 19 (42.2% of the total number); the patients of iliac vein thrombosis was 10 (22.2% of the total number) by anterograde lower extremity anterograde venography imaging. The deep venous thrombosis of lower extremity with thrombosis of inferior vena cava is 7 (15.6% of the total number) by vena cava angiography. There are 45 cases with iliac vein patency or incomplete occlusion in all patients, most patients with mild to moderate swelling or no swelling. Conclusion The patients of lower limb swelling of the lower extremities deep vein thrombosis are more easily complicated by pulmonary embolism; iliac vein patency and thrombosis of inferior vena cava is very dangerous in the disease of venous thromboemlism through anterograde vein venography.