Abstract: Objective To explore effect of the nursing intervention for patients with coronary heart disease, diabetes mellitus coronary artery interventional treatment on complications. Methods From January, 2014 to October, 2014, 114 cases of hospitalized patients with interventional therapy of coronary artery disease patients with diabetes as the main object of observation were randomly divided into observation group and the control group, with 57 cases in each group. Apply nursing intervention to observation group, and control group using conventional care. After 1 year of follow-up, we compared the incidence of complications and clinical indicators (systolic blood pressure and fasting blood sugar) between the two groups of patients after coronary artery intervention treatment. And quality of life of patients is evaluated; the results were statistically analyzed via t-test. Results We observed a complication rate of 45.61% in observation group which was obviously lower than 94.74% in the control group with statistical significance (t=-2.409; P=0.0085). Systolic blood pressure in patients with nursing intervention of observation group was obviously lower. Fasting glucose values were significantly closer to normal. The clinical index in observation group outperformed that in the control group (P<0.05). With diabetes specific evaluation of the quality of life scale, the total score and several dimensions in observation group were significantly lower than the control group after evaluation, with statistical significance (P<0.05). Conclusion Nursing intervention can effectively avoid the incidence of the complications after coronary artery intervention in patients with risk, maintain systolic blood pressure, make fasting blood glucose value return to normal, lower systolic blood pressure and fasting blood sugar, and improve the quality of life of patients with diabetes. It helps to improve the rehabilitation status and social function recovery, and the application effect is good, with lower clinical medical cost.