Abstract: Objective To study the effects of collaborative nursing model on the toxicity of chemotherapy combined with TACE in the treatment of gastric cancer with liver metastasis. Methods From January, 2014 to March, 2016, 80 cases of patients with liver metastases from gastric cancer were diagnosed in our hospital. All patients were treated with unified chemotherapy and TACE treatment. The patients were randomly divided into observation group (40 cases) and control group (40 cases). Via SPSS 22.0, the depression before and after the treatment, toxic and side effects of the treatments were compared with t test. And the satisfaction of nursing work was analyzed with variance analysis. Comprehensive evaluation of collaborative care model on the incidence of adverse reactions in patients with liver cancer was made. Results The depression score of patients in the observation group after 14 days of treatment had significant difference compared to that before admission (P<0.05); depression scores of the observation group and those of the control group after 14 days of treatment had significant difference (P<0.05); between collaborative care group and routine nursing group, nausea and vomiting, mucositis, renal dysfunction, infection, bone marrow suppression rate were lower, with statistical significance (P<0.05); the satisfaction rate of 36 cases in the observation group was 90%, significantly higher than that of 29 cases in the control group which was 72%, and the difference was statistically significant (P<0.05). Conclusion Collaborative nursing model of chemotherapy combined with TACE in the treatment of gastric cancer with liver metastasis can reduce the negative emotions of patients, reduce the adverse reaction rate, reduce the pain of patients, provide high compliance of the patients and help patients smoothly complete treatment plan.