Abstract: Objective To observe the comprehensive clinical efficacy of catgut-embedding therapy combined with biofeedback on the treatment of functional constipation(FC), and provide a more comprehensive treatment method for them. Methods The 80 cases of FC were selected from March, 2014 to March, 2016 in Anorectal department in Tongde Hospital of Zhejiang Province. They were randomly divided into control group and observation group according to their hospital admission orders. Biofeedback therapy was given to 40 cases in control group once a day, with 30 days as 1 course. Catgut-embedding therapy combined with biofeedback was given to 40 cases in observation group 15 days 1 time, cv 2 times for 1 course. After the treatment, we compared with the clinical efficacy of the two groups, and observed the improvement of main clinical symptoms before and after treatment. The evaluation of quality of life were based on the health survey questionnaire(SF-36). We used statistics software SPSS 22.0 for the research of statistical data. Results After treatment, the clinical total effective rate of the observation group and the control group were 89.74% and 71.05% respectively, and there were significant differences(P<0.05). The main symptoms of the two groups were significantly improved after treatment(P<0.05), and the improvement rate of the observation group was significantly better than the control group(P<0.05). After treatment each dimension score of two groups were obviously improved(P<0.05). In addition to the physiological function and body pain, the observation group improvement were significantly better than that of control group(P<0.05). Conclusion Catgut-embedding therapy combined with biofeedback in the treatment of functional constipation is better than biological feedback. They can effectively improve the patient's clinical symptoms, and can also improve the quality of life of the patients.