Abstract: Objective To observe the correlation between the CT perfusion parameters and the expression of vascular endothelial growth factor(VEGF) in postoperative recurrence of laryngeal cancer. Methods Forty postoperative recurrence of laryngeal cancer were scanned by spiral CT, and to calculate the perfusion parameters with perfusion functional software. The parameters included blood flow(BF), blood volume(BV), mean transit time(MTT) and permeability surface(PS). And the serum VEGF specimens were detected by sandwich enzyme-linked immunosorbent assay(ELISA) and 20 non-postoperative recurrence of laryngeal cancer as contrast. The correlation between the CT perfusion parameters and VEGF was studied. Results CT perfusion parameters(BF, BV, MTT and PS) were difference between non-postoperative recurrence and postoperative recurrence lesions of laryngeal cancer. BF of postoperative recurrence group was higher than that of postoperative recurrence lesions group(P<0.05). In postoperative recurrence, BF and BV was positively correlated with VEGF(r=0.471, 0.389, P<0.05), MTT and VEGF showed a negative correlation(r=-0.427, P<0.05), there was not correlative between PS and VEGF(r=0.302, P>0.05). Conclusion CT perfusion parameters of postoperative recurrence of laryngeal cancer are correlated with VEGF, which may reflect the expression of VEGF. The CT perfusion should be helpful to diagnosis and treatment postoperative recurrence of laryngeal cancer.