Abstract: Objective To explore the influences of predictive nursing intervention on the quality of life of patients with gastric cancer after radical gastrectomy. Methods From August, 2012 to February, 2016, 132 patients with gastric cancer in our hospital for diagnosis and treatment were selected and randomly divided into observation group and control group, with 66 patients in each group. All patients received laparoscopic radical gastrectomy, while the control group was given routine nursing care in the perioperative period, and the observation group was given nursing intervention based on the control group. We observed and recorded recovery of patients in both groups. Results All patients had successfully completed surgery and no serious complications occurred during the operation. The postoperative bowel sound recovery exhaust time, hospitalization time and anal exhaust time in the observation group[(19.03±5.23) h, (76.76±22.30) h, (12.29±1.84) d respectively] were significantly less than those in the control group[(25.98±6.76) h, (89.55±21.84) h, (16.39±1.73) d]respectively(P<0.05). One month after the operation, complication rate of anastomotic fistula, incision infection, pulmonary infection, intestinal obstruction and fever in the observation group was 4.5%, which was significantly less than 21.2% in the control group(P<0.05). One month after the operation, the scores of cognitive function, physical function, role function, emotional function, and social function of the observation group were significantly higher than those of the control group(P<0.05). Conclusion The predictive nursing intervention can promote the recovery of patients with gastric cancer after radical gastrectomy, reduce the incidence of postoperative complications, and the patients can benefit from the surgery to maximize the quality of life.