Abstract: Objective This study is based on the purpose of "high-quality nursing service"(close to the clinical, close to the patient, close to the community, to provide patients with safe, effective, whole-course, seamless, satisfactory care services), to design an intelligent dress for the patients with nasopharyngeal carcinoma. It mainly aims to explore the application of intelligent dress as a new method for the nursing care of the patients with nasopharyngeal carcinoma, and to observe its clinical application effects. Methods A total of 213 cases of nasopharyngeal carcinoma patients from February, 2015 to January, 2016 were divided into two groups. Collected from February, 2015 to July, 2015, 107 cases provided with traditional dress were used as the control group, and 106 cases provided with intelligent dress collected from August, 2015 to January, 2016 were used as the intervention group. Comparisons of the satisfaction for nurses, incidence of grade-Ⅲ radiation dermatitis, incidence of grade-Ⅳ radiation dermatitis were performed between the two groups. Results The satisfaction rate[104(98.1%) vs. 6(5.6%), χ²=178.78, P=0.001] and nurse satisfaction rate[106(100.0%) vs. 3(2.8%), χ²=200.39, P=0.001] were significantly increased in the intervention group. The incidence of grade-Ⅲ radiation dermatitis[3(2.8%) vs. 15(14.0%), χ²=7.23, P=0.007] was significantly lower in the intervention group than those in the control group(P<0.05). Conclusion Intelligent dress can effectively meet the needs of the nursing care for the patients with nasopharyngeal carcinoma, and the process of wearing off is convenient. Intelligent dress is also convenient for medical care operation and observation, improve the satisfaction, and reduce the incidence of grade-Ⅲ radiation dermatitis, with low economic costs. It is worthy of promoting the use of intelligent dress in head and neck cancer ward.