Abstract: Objective To investigate the effects of continuous care on psychological state and medication compliance of patients with acute myocardial infarction after percutaneous coronary intervention (PCI), thus to choose the optimal nursing strategies. Methods We selected 90 patients with acute myocardial infarction after PCI from January, 2016 to May, 2017 treated in the cardiology department in the affiliated hospital of Hangzhou Normal University and randomly divided them into two groups, with 45 cases in each group. The control group received routine care, on the basis of which the observation group received continuous care including regular follow-up, medication guide, and health education. The scores of anxiety, depression, nursing satisfaction and medication compliance were compared between the two groups at the time of discharge 3 or 6 months after discharge. Results By comparison, the anxiety and depression scores when discharged from hospital displayed no significant difference between groups. After 3 months' discharge, the anxiety and depression scores of the observation group were (35.76±6.54), (32.21±5.55), and the control group were (38.15±2.32), (35.78±2.17). After 6 months of discharge from hospital, those in observation group were (32.51±2.54), (30.21±4.45), and the control group (35.45±4.02), (34.78±2.03) in the observation group, which were lower than those in the control group. Medication compliance scores in the observation group at discharge, 3 months and 6 months after discharge from hospital were (9.3±1.3), (12.3±1.4), (14.2±0.4) respectively; those in the control group were (8.3±2.6), (9.6±2.3), (10.3±1.9). And 6 months after discharge, the satisfaction of the observation group was 95.6%, and that of the control group was 77.8%. The two groups had statistical significance (P<0.05). Conclusion Continuous care of patients with acute myocardial infarction after PCI could improve patient compliance together with patients satisfaction, reduce depression, anxiety and other negative emotions, and help to promote the rehabilitation of the patients, which is worthy of promotion.