Abstract: Objective To observe the clinical curative effect of oseltamivir in the treatment of flu-like children. Methods A total of 87 cases of flu-like children accepted by the first affiliated hospital of Bengbu Medical College between September, 2017 and November, 2017 are randomly divided into two groups. They are oseltamivir group and control group with 44 and 43 cases respectively. The oseltamivir group are treated with reduning injection and oseltamivir granules, and the control group reduning only. Both groups are treated for 5 consecutive days, to be observed on the development, side effect, and prognosis, so as to find out the curative effect and safety of oseltamivir. Results There is no significant difference between the normal condition, severity and blood routine of both groups before treatment. The time of fever's coming down of oseltamivir group is (27.52±6.32) h. It is shorter than that of control group with the time of (36.13±8.51) h. The difference is statistically significant (P<0.05). The total effective rates of the two groups are 93.2% and 76.1% respectively. The total effective rate of oseltamivir group is higher than that of control group. The difference is statistically significant as well(P<0.05). There are 4 cases from oseltamivir group and 2 cases from control group which are tested for H1N1. Two of oseltamivir group and that two from control group are positive. However, the sample is too small to do statistical test. There are 3 cases of nausea and vomiting in oseltamivir group,and getting better after changing the way of taking medicine. Conclusion Comparing the oseltamivir group and control group of cases accepted by the first affiliated hospital of Bengbu Medical College, the fever's coming down time of oseltamivir group is significantly shorter than that of control group. Oseltamivir is mild in side effect and safe to use. Therefore, it is worthy to popularize.