Abstract: Objective To study the clinical application effect of different polyamide gauze in the acute and chronic wound healing process. Methods A total of 137 cases of hospitalized patients of department of burn and plastic surgery and emergency, the first affiliated hospital of Chengdu Medical College, from January, 2016 to November, 2016 were selected and divided into experimental group (n=68) and control group(n=69) according to the random number table method. There was no significant difference between the two groups in age, sex, and wound surface. Two groups of patients were treated by the same method of debridement, disinfection and marking photography. After photography, the experimental group of acute and chronic wounds was given polyamide gauze on the wound, and the control group of acute and chronic wounds given Vaseline gauze on the wound. Note the time of wounds healing and seepage stopping, and the score of VAS. And take photos. The wound healing time, wound bleeding time and the pain score during dressing change were statistically analyzed, and the clinical effects of the two groups were compared. Results Polyamide gauze and Vaseline gauze both can play the role of promoting wound healing, without statistical significance (P>0.05), but the experiment group is better than control group in healing time, seepage stop time and VAS score was statistically significant (P<0.05). Conclusion Polyamide gauze as a new material has a better treatment effect than Vaseline gauze applying at various acute and chronic wound healing process, and the clinical application is more advantageous, which is worth popularizing.