Abstract: Objective To investigate the effect of nalmefene combined mild hypothermia on neurological function of patients with cardiopulmonary resuscitation. Methods Sixty-eghit patients with cardiopulmonary resuscitation (CPR) from February, 2012 to February, 2016 were randomly divided into two groups, 34 cases in each group. The control group was given mild hypothermia, and the research group was added nalmefene. All patients were continued treated for 3 d. The rectal temperature, Glasgow Coma Scale (GCS), neurological deficit score (NFI), BI index score and 30-day mortality of two groups were compared. Results Before treatment, there was no significant difference on rectal temperature between two groups (P>0.05). After treatment 5 hours, the rectal temperature of two groups was significantly reduced compared with that of before treatment (P<0.05), but there was no significant difference between two groups (P>0.05). Before treatment, there was no significant difference on GCS score between two groups (P>0.05). After treatment, the GCS score of two groups was significantly improved compared with that of before treatment (P<0.05), GCS score of research group was significant higher than that of control group (P<0.05). After treatment, the NFI and BI scores of two groups were significantly improved (P<0.05), and the NFI score of the research group was lower than that of control group (P<0.05), the BI score of the research group was higher than that of control group (P<0.05). The fatality rate of research group was 17.65%, which was significantly lower than that of control group (41.18%, P<0.05). Conclusion Nalmefene combined mild hypothermia could effectively treat patients with cardiopulmonary resuscitation, significantly improve their neurological function, daily living activities and health status, reduce mortality, with the promotion value.