Abstract: Objective To investigate the effects of fascia iliaca compartment block (FICB) combined with laryngeal mask airway in children undergoing femoral surgery. Methods Eighty children with femoral shaft fracture undergoing selective surgery were randomly divided into experiment group and control group (n=40). FICB combined with laryngeal mask airway were implemented into the experiment group, while general anesthesia with intubation was performed in the control group. After intubation, FICB was implemented under ultrasonic guidance in the experiment group. Anesthesia was maintained with propofol and sevoflurane to keep the bispectral index value between 45 and 55 and control the hemodynamic response to the surgical procedure within a 20% range of the preoperative value. Hemodynamic parameters were monitored, and postoperative pain was accessed by visual analogue scale within 24 hours and the requirements of propofol and sulfentanly were recorded. Postoperative complications were observed, such as time in Post Anesthesia Care Unit and time to extubation. Results Hemodynamic parameters in the experiment group were significantly higher than those in the control group (all P<0.05). The difference in VAS value for FICB was significant between the two groups at 4-12 h postoperatively (all P<0.05); when compared with control group, the dosage of propofol and sulfentanly was significantly less in the experiment group, and the time to extubation and time in postoperative anesthesia recover unit was shorter (all P<0.05). Additionally, the incidence of postoperative complication was less in the experiment group as compared with the control group. Conclusion FICB combined with laryngeal mask airway is superior to general anesthesia with intubation in children undergoing femoral surgery with less complications.