Abstract: Objective To investigate the clinical value of color ultrasound in perioperativepatients with carotid endarterectomy. Methods A total of 53 breast cancer patients were selected in our hospital from February, 2015 to March, 2017. All of patients treated with carotid endarterectomy. To observe lesion location, degree of coronary artery stenosis, narrow blood vessels, hemodynamic index changes and postoperative prognosis during perioperative stage. Results There were 84 cases of arterial stenosis in 53 patients, including 20 patients with unilateral lesions and 32 patients with bilateral lesions. Consistency was good between color ultrasound detection and DSA detection (Kappa=0.857, P<0.001); After suture of carotid artery, 33 thin strips of high echo were detected by color doppler ultrasonography in 22 patients, including 31 for mild abnormalities which were < 3 mm free internal diaphragm, and the other two is significantly abnormal which were Zonal thrombus; The endovascular diameter and hemodynamic indexes were significantly improved after operation (all P<0.01); Within 3 months after operation, the mortality rate of the patients was 0, 3 patients with cervical hematoma, 1 patient with hyperplasia and edema of surgical site, 1 case with ischemic cerebral infarction whose color ultrasound showed the various free internal diaphragm of < 2 mm. Conclusion Color ultrasound has important clinical application value on preoperative diagnosis, intraoperative evaluation and postoperative prognosis in patients with carotid endarterectomy.