Abstract: Objective To explore the efficacy and safety of minimally invasive approach biodegradable screw and protection of the lateral calcaneal bone flap in the treatment of calcaneal fracture with the lateral displaced articular fragments. Methods A retrospective study was conducted to analyze the 37 patients of calcaneal fracture with the lateral displaced articular fragments who had been treated with invasive approach biodegradable screw and protection of the lateral calcaneal bone flap at our hospital from January, 2010 to January, 2014. The data were analyzed concerning age, gender, complications of different systems, smoke history, damage factor, fracture type, operation time, bleeding volume, complications of operation, fracture heeling and functional recovery. Results Thirty-seven patients were followed up for 24 to 38 months, average 12 months. The pre-post-operative Bohler's angle and Gissane's angle was significant difference(P<0.05). The degree of postoperative Bohler's angle and Gissane's angle have large than peroperative angles. There were no problems with wound healing or necrosis during the follow-up. The excellent and good rate was 87.8%. Conclusion In treatment calcaneal fracture with the lateral displaced articular fragments, the minimally invasive approach biodegradable screw and protection of the lateral calcaneal bone flap is a successful treatment. The advantages include shorter operation time, limited trauma, and reduced postoperative complications. This technique can be considered in patients who are not suitable for an extensile lateral approach and internal fixation.