Abstract: Objective To compare the clinical features of acute severe poisoning of phorate and other non-phorate pesticide. Methods There was a retrospective analysis of 50 cases of patients with severe organophosphorus poisoning in our hospital from March, 2014 to March, 2017,which were divided into phorate poisoning group (22 cases) and other non-phorate poisoning group (28 cases) according to different toxicity of pesticide. The intermediate syndrome cases, cholinesterase recovery time, the total amount of penehyclidine hydrochloride dosage, tracheotomy cases, hospitalization time and fatality rate were observed. Results Compared with other non-phoratepoisoning group:①phorate poisoning group has a higher incidence of intermediate syndrome (14 vs. 0); ②longer cholinesterase recovery time[(330.55±8.64) h vs. (67.71±6.42) h]; ③higher penehyclidine hydrochloride dosage[(58.00±12.92) mg vs. (8.35±2.66) mg]; ④more cases of tracheotomy (18 vs. 2); ⑤longer hospitalization period[(19.50±6.39) d vs. (10.57±3.54) d]. There was a significant difference in above clinical observation indexes between the two groups (P<0.05); ⑥The fatality rate of phorate poisoning group was 4.54%, and the fatality rate of non-phorate poisoning group was 7.14%. There was no difference in fatality rate between the two groups (P>0.05). Conclusion Acute phorate poisoning has many complications, long hospitalization time and heavy follow-up treatment burden.