Abstract: Objective To investigate the efficacy of Sinupret drops in treatment of children with rhinosinusitis and the effects of the levels of interleukin-10 (IL-10), interleukin-2 (IL-2), C reactive protein (CRP) and tumor necrosis factor-α (TNF-α) levels. Methods Three hundred cases of children with rhinosinusitis were randomly divided into the observation group (n=150) and the control group (n=150). The observation group was treated with Sinupret Drops and the control group with oral ambroxol syrup, were 3 times/day, 2 weeks. The two groups respectively before and after treatment by visual analogue scale (VAS) and nasal outcome test-20 (SNOT-20) scale were used to assess the degree of children with disease, and the ELISA were used to detect the serum IL-2 and IL-10, TNF- alpha and CRP level change. Results The nasal congestion, cheek pain or pain, headache, hyposmia score in the two groups after treatment were significantly lower than those before treatment (P<0.05), and the observation group was significantly lower than the control group (P<0.05). The nasal symptoms, associated symptoms, sleep disorder and affective outcome scores in two groups after treatment were significantly lower than those before treatment (P<0.05), and the observation group was significantly lower than the control group (P<0.05). The total effective rate of the observation group was significantly higher than that of the control group (χ²=12.997, P<0.001). The serum IL-10, IL-2, CRP and TNF-α levels in two groups after treatment were significantly lower than those before treatment (P<0.05), and the serum IL-10 (241.18±26.37 vs. 310.25±30.64), IL-2(24.37±4.42 vs. 30.08±4.35), CRP(3.05±0.26 vs. 4.92±0.48) and TNF-α(1.08±0.20 vs. 1.95±0.41) levels in observation group were significantly lower than those in the control group(P<0.05). Conclusion Sinupret Drops has better effect in treatment of children rhinosinusitis, and it can relieve the children's inflammation.