Abstract: Objective To investigate the effect of Renshen Hajie power combined acupoint injection on immune function, IL-2 and sIL-2R of patients with stable COPD. Methods A total of 130 patients with stable COPD were randomly divided into two groups, each group 65 cases. The control group was given Western medicine treatment, and the observation group was given Renshen Hajie power combined acupoint injection based on control group. The lung function, immune function, IL-2 and sIL-2R, and life quality of two groups were compared. Results After treatment, FEV1, FEV1% and FVC of two groups were significantly increased (P<0.05), and observation group was higher than control group (P<0.05). After treatment, CD3⁺, CD4⁺, CD4⁺/CD8⁺ of two groups were significantly increased (P<0.05), and the observation group was higher than control group (P<0.05). After treatment, IL-2 of two groups were significantly increased (P<0.05), and the observation group was higher than control group (P<0.05). After treatment, sIL-2R of two groups were significantly decreased (P<0.05), and the observation group was lower than control group (P<0.05). After treatment, the respiratory symptoms, activities status, disease influence and total score of two groups were significantly reduced (P<0.05), and the observation group was significantly lower than the control group (P<0.05). Conclusion Renshen Hajie power combined acupoint injection could effectively improve the immune function of patients with stable COPD. The mechanism might be achieved by improving IL-2 and sIL-2R, thereby enhancing lung function and life quality of patients.