Abstract: Objective To observe the effect Ciluxiaozhongyin on upper limb lymphedema of patients with breast cancer after surgery. Methods A total of 60 patients with upper limb lymphedema after breast cancer surgery were selected in the First Affiliated Hospital of Bengbu Medical College, Chinese medicine oncology department, tumor surgery and radiotherapy department from August, 2016 to December, 2016, which were divided into the observation group and the treatment group by simple random grouping, with 30 cases in each group. And 30 cases in the observation group were given Diosmin 0.5 orally two times a day, limb function exercise and local massage; the treatment group of 30 cases in the observation group on the basis of such treatment were given Ciluxiaozhongyin, decoction two times a day morning and evening for 4 weeks. T test and rank sum test were used to observe the changes of upper limb edema, upper limb pain and clinical curative effect of TCM in the two groups. Results Compared with the observation group with 56.7% efficiency in upper limb edema, the treatment group with 83.3% efficiency was improved significantly (P<0.01); Compared with the observation group, with 53.3% efficiency, in upper limb pain the treatment group with 86.7% efficiency was better, the difference was of significance in statistics science (P<0.05); Without treatment the difference in comparison of TCM syndrome integral was not of significance in statistics science (P>0.05), while after treatment the result is opposite(P<0.05). TCM syndrome integral of treatment declined more apparently than the observation group, with statistical significance (P<0.05). Conclusion Ciluxiaozhongyin can significantly promote breast cancer postoperative upper limb lymphedema, relieve the pain, and improve the quality of life of patients.