Abstract: Objective To explore the advantages of the concept of transformation medicine and case discussion in the clinical teaching of gastroenterological surgery. Methods A total of 120 of gastrointestinal surgery interns from June, 2016 to May, 2017 in our hospital were randomly divided into control group and experimental group, with 60 cases in each group. The students in the control group took traditional teaching methods, and experimental students in the experimental group carried out the concept of translational medicine combined with case discussion and clinical practice teaching mode. After one month of teaching, two teaching forms were evaluated by questionnaire and theoretical examination, and to observe and compare the average scores and other related indicators of the students in the two groups. Results There was no significant difference in the comparison of the basic data between the two groups of students (P>0.05); The test scores of the students in the experimental group was significantly higher than the control group(P<0.05); The students in the experimental group increased the ability to explore the clinical interest, refine the ability of scientific research thinking, increase the depth and breadth of learning, and promote the ability of independent thinking and self-learning were higher than those of the control group, with statistically significant difference (P<0.05); The teaching effect of the experimental group students interested in teaching mode and approving case discussion was higher than that of the control group, and the difference was statistically significant (P<0.05). Conclusion Translational medicine combined with case discussion in clinical teaching of gastrointestinal surgery enjoys a significant advantage, breaks through the shortcomings of the traditional teaching method, suitable for the modern clinical practice teaching, to adapt to the modern medical teaching requirements, teaching advantages, improves the exam results, increasing the ability to explore clinical interests, refining research ideas, increasing the depth and breadth of learning, and promoting independent thinking and autonomous learning, strengthens the cultivation of innovative thinking and is of great significance to enhance the clinical skills of medical students, and is worthy of popularizing in clinical use in the teaching of gastrointestinal surgery.