Abstract: Objective To explore the psychological resilience of nurses in intensive care unit (ICU) in three grade general hospital and its related influencing factors, so as to provide evidence for psychological intervention of ICU nurses. Methods Connor-Davidson psychological scale was used to investigate the psychological elasticity of 1 082 ICU nurses in three general hospitals in Hainan Province from January, 2017 to March, 2017, and the influencing factors were analyzed by multiple Logistic regression. Results The average score of resilience of ICU nurses (57.61±14.16) was significantly lower than that of the national norm (65.4±13.9), and the difference was statistically significant (P<0.01). Correlation analysis showed that resilience and its 3 dimension scores were positively related to ICU nurses' educational background, working years and night shift (P<0.05). There were significant differences in psychological resilience scores of ICU nurses between different gender, educational background, professional title, working years, night shift status, employment characteristics, workplace violence experience, and workplace tension (P<0.05). Multivariate Logistic regression showed that educational background, working years and night shift were the main factors influencing the resilience of ICU nurses[OR=1.928, 95%CI:1.214-3.013; OR=1.627, 95%CI:1.085-2.683; OR=2.064, 95%CI:1.542-3.117]. ROC curve was used to evaluate the effect of logistic regression model, and its AUC (95%CI) was 0.924 (0.875-0.996). Conclusion The psychological resilience of ICU nurses is low, and there are many factors affecting their resilience. The nursing managers should intervene according to the corresponding factors so as to improve the psychological status of ICU nurses.