Abstract: Objective To explore the nursing intervention for multiple effects on polysomnography in patients with sleep apnea syndrome. Methods A total of 162 cases of the patients with polysomnography sleep apnea syndrome in respiratory medicine department of our hospital were randomly divided and all patients underwent polysomnography examination. The control group of 81 cases treated with conventional symptomatic nursing, 81 cases of the study group to monitor the whole process of nursing intervention, observe and record the two groups of monitoring and monitoring the success rate of failure, the score of anxiety, comfort, knowledge awareness, comparison of nursing satisfaction rate at the same time. Results In the control group, the success rate of monitoring (85.19%) was lower than that in the study group (95.06%), with statistical significance (P<0.05); the main reasons for the failure of the monitoring include environment change leading to less sleep time, the electrode off without timely recovery, shedding gas off, the SPO₂ signal getting lost, diarrhea at night. That the control group did not timely remedy electrode loss was significantly higher than that in study group, with statistical significance (all P<0.05); compared with the control group, after polysomnography nursing anxiety score was lower in study group, comfort degree, knowledge degree is higher, with statistical significance (all P<0.05); nursing satisfaction rate of the control group (79.01%) was lower than the study group (97.53%), with statistical significance (P<0.05). Conclusion Nursing intervention can improve the sleep apnea syndrome patients underwent polysomnography comfort and relevant knowledge, alleviate the anxiety of patients; improve nursing satisfaction rate as well as success rate of monitoring.