Abstract: Objective To investigate the incidence and risk factors of HELLP syndrome of severe preeclampsia, and provide clinical data for reduce the HELLP syndrome. Methods The clinical data of 182 patients with severe preeclampsia from January, 2007 to January, 2017 in Obstetrices and Gynecology of Jin Hua. The patients were divided into HELLP group and non- HELLP group, according to the HELLP syndrome. The related factors which may be induced HELLP syndrome were analyzed, and the related factors was analyzed by logistic regression analysis. Results In 182 cases of severe preeclampsia patients,including 36 cases of patient with HELLP syndrome, the incidence was 19.78%. Single factor analysis and multi-factor logistic regression analysis shows that the early onset preeclampsia (OR=3.533, P=0.012, 95% CI:1.421-9.744), maternal age (OR=4.995, P=0.003, 95% CI:1.671-10.651) was risk factors of severe preeclampsia complicated with HELLP syndrome. Regular examination (OR=0.241, P<0.001, 95%CI:0.080-0.721) was protective factor for severe preeclampsia complicated with HELLP syndrome. Conclusion HELLP syndrome was the complications of and the elderly women with early onset preeclampsia should be regularly examined, screening high-risk factors, in order to reduce the incidence of HELLP syndrome.