Abstract: Objective To explore the effects of social support intervention on the care of the family members of patients with acute myocardial infarction via correlation analysis. Methods From February, 2014 to December, 2016, 88 family members of patients with acute myocardial infarction in our hospital were selected as the observation group, and the other 88 locals with healthy family members were selected as the control group. Via CBI, SSRS and SCL-90, the two groups were given investigation and analysis of the relationship among the social support, quality of life and care burden. Results The time dependent burden, the limited development burden, the physiological burden, the social burden and the emotional burden scores in the observation group were significantly higher than those of the control group (P<0.05). The objective support, subjective support, utilization degree of social support in the observation group were significantly lower than those in the control group (P<0.05), and somatization, obsessive-compulsive symptoms, interpersonal sensitivity, depression and anxiety score quality of life scores in the observation group were significantly higher than those in the control group (P<0.05). Spearman correlation analysis showed that the dimensions of social support scores, quality of life scores were positively correlated to the time dependency burden scores (P< 0.05), the dimension of social support scores, somatization, obsessive-compulsive symptoms, depression scores were positively correlated to the emotional burden (P<0.05), the social support utilization scores were positively correlated with social burden (P<0.05), the objective support scores were correlated with the limited development burden (P<0.05). Conclusion The burden of family members of patients with acute myocardial infarction is relatively heavy, together with low social support and quality of life. We should strengthen the social support intervention that can improve the patient's family care ability and quality of life.