Abstract: Objective To evaluate the clinical value of contrast-enhanced ultrasonography in the diagnosis of hepatic hemangioma. Methods A total of 82 patients with suspected hepatic hemangioma received from February, 2015 to February, 2017 were enrolled in this study. All patients were diagnosed by enhanced CT or MRI, followed by conventional ultrasound and ultrasonography. Test diagnosis, observation of diagnostic sensitivity, specificity, misdiagnosis rate, missed diagnosis rate and Youden index, observe the image diagnosis performance. Results Totally 64 lesions were identified by pathology in 57 patients. The sensitivity, specificity and specificity of contrast-enhanced ultrasound in the diagnosis of hepatic hemangiomas were 87.72%, 80.00%, 0.68 for Youden index and 0.662 for Kappa, respectively. The sensitivity of routine ultrasound was 59.65% Degree of 68.00%, Youden index of 0.28, Kappa value of 0.237; contrast-enhanced ultrasound in the diagnosis of hepatic hemangiomas sensitivity was significantly higher than conventional ultrasound, the difference was statistically significant (χ²=11.581, P<0.001); conventional ultrasound in 34 cases 8 cases were misdiagnosed and missed by 23 cases. Among the 59 lesions found by contrast-enhanced ultrasound, CEUS showed two enhancement modes:① the perimeter was completely filled to the center and 35 lesions; ② filling time is shortened, the overall enhancement, 14 lesions, at the same time found 4 low-echo lesions, 5 patients were misdiagnosed, 7 patients were missed. Conclusion Ultrasonography can be used to diagnose hepatic hemangioma with high sensitivity and specificity. The rate of missed diagnosis and misdiagnosis rate is low, which can effectively distinguish between high and low echo foci and deserve clinical promotion.