Abstract: Objective To observe the application of CNP in combing flap transplantation with VSD in chronic osteomyelitis. Methods From May, 2013 to May, 2015,100 patients in TCM of Wenzhou hospital with chronic osteomyelitis were randomly divided into two groups and were given flap transplantation and VSD treatment. The control group was given routine nursing treatment, while the study group was treated by CNP. The hospitalization, wound healing time, VAS score, full weight-bearing time, dressing change times, catheterization time, hospitalization costs, recurrence rate, satisfaction rate, SAS, SDS, quality of life scores and curative effect were reviewed and compared in the two groups. The criteria for efficacy evaluation refer to the WHO's chronic osteomyelitis standard. Results The hospitalization[(5.29±1.31) weeks], wound healing time[(4.36±1.25) weeks], VAS score[(2.53±0.46) score], full weight-bearing time[(4.95±1.83) months], dressing change times (3.05±0.82), catheterization time[(9.65±1.82) day], hospitalization costs[(1.16±0.83) ten thousands yuan], SDS[(32.19±5.48) score], SAS[(37.24±5.06) score] in the research group were less than those in the control group without recurrence while the quality of life scores[(77.89±8.25) score], satisfaction rate (94%) and curative effect (94%) in the research group were higher than those in the control group with statistical significance (P<0.05). Conclusion The application of CNP in combing flap transplantation with VSD in chronic osteomyelitis can regulate the behavior of doctors and nurses, effectively control infection, repairing bone and skin soft tissue defect, promoting wound and fracture healing, relieving pain, shorten the hospital stay, improving nursing quality and reducing recurrence rate. The curative effect was promising.