Abstract: Objective To investigate the efficacy of the rehabilitation nursing with the seasons' change of time combined with psychological counseling in treating patients with depression of stroke hemiplegia. Methods One hundred-four patients with post-stroke depression were chosen and randomly divided into control group and treatment group. All cases were given routine treatment referring to "Chinese stroke rehabilitation treatment guidelines". We regulated their blood sugar and blood fat level and blood pressure, corrected water electrolyte disorder, treated them with neurotrophic drugs, used oxygen uptake and infection prevention if necessary, and took orally aspirin enteric-coated metformin hydrochloride. Control group received Flupentixol and Melitracen every day with 1 tablet in morning. Based on the control group, treatment group was treated with the rehabilitation nursing with the seasons' change of time (on the day of admission, 2 days in hospital, and post-discharge) combined with psychological counseling according to the patient's individual differences. Efficacy was evaluated after 6 weeks. Scores of SDS, HAMD scale, and CSS were compared between two groups. Efficacy was analyzed in both groups. Results SDS score of treatment group was evidently lower than control group after 3 and 6 weeks' treatment (P<0.01). After treatment, scores of HAMD scale factors of treatment group were lower than those in control group (P<0.01). Total efficacy rate of treatment group was 92.31%, which was higher than control group as 76.92% (P<0.05). CSS score of treatment group was obviously lower than control group after 6 and 12 weeks' treatment (P<0.01). Conclusion Rehabilitation nursing with the seasons' change of time combined with psychological counseling in treating patients with depression of stroke hemiplegia can improve depression, and promote recovery of neural function.