Abstract: Objective To observe the effect of the combination of sufentanil and lornoxicam on preventing postoperative agitation in patients undergoing sevoflurane anaesthesia for endoscopic sinus surgery. Methods Total 60 patients undergoing endoscopic sinus surgery during sevoflurane anesthesia were enrolled into this study. There were 39 men and 21 women, ranging from 20 years old to 60 years old. Both of them belonged to the ASA Ⅰ or Ⅱ. The double-blind experiment design was applied. According to the random number table, these patients were divided into three groups:the sufentanil group (S group), sufentanil+lornoxicam group (SL group) and the control group (C group), with 20 patients in each group. The inhalation anesthesia was used in all the three groups. During the operation, sevoflurane combined with the remifentanil was applied to maintain depth in the whole process. These patients were injected with sufentanil 0.2 μg/kg (S group), sufentanil 0.1 μg/kg+lornoxicam 8 mg (SL group) and equivalent 0.9% sodium chloride solution (C group) through the veins before finishing surgery for 30 min. The tube drawing time, recovery time, dysphoria after tube drawing, VAS scoring and post-operative 24 h nausea and vomiting occurrence of each group were observed. Results By comparing with the C group, postoperative agitation after tube drawing in S and SL groups was obviously reduced. VAS scoring was obviously reduced (P<0.05). There was no statistical significance between S group and SL group (P>0.05). The tube drawing time and recovery time of SL group and C group were reduced. The occurrence of nausea and vomiting during post-operative 24 h was reduced (P<0.05). There was no statistical significance between SL group and C group (P>0.05). Conclusion Intravenous injection of sufentanil and lornoxicam can reduce postoperative agitation in patients undergoing endoscopic sinus surgery during sevoflurane anesthesia. And it won't affect postoperative recovery, tube drawing time, and occurrence of nausea and vomiting during post-operative 24 h.