Abstract: Objective To investigate the change of balance function and its related factors in Parkinson's disease, the aim is to provide reference value for clinical prevention and treatment. Methods Two hundred and seventy-nine patients with Parkinson's disease who were admitted to our hospital from January, 2015 to January, 2017 were selected, in terms of balance dysfunction was divided into 90 cases of normal balance function group and 189 cases of balance dysfunction group. The factors such as gender, age, course of disease, educational level and visual condition were investigated. Results Two hundred and seventy-nine patients with Parkinson's disease showed balanced dysfunction in 189 cases (balanced dysfunction group), the incidence was 67.74%; 90 patients with normal balance function (balanced function normal group) 32.26%. The Berg balance scale (BBS) score and Dynamic fall risk index (DFI) score of the balanced dysfunction group were lower than that of the normal group, and the Static fall risk index (SFI) score was higher than that of the normal group with balanced function (P<0.05). After the intervention, the BBS score and DFI score were higher than those before intervention, and the SFI score was lower than that before intervention (P<0.05). The single factor analysis showed that there was no significant difference in gender, education level, Parkinson family history, antidepressants and sedative drugs in the balance dysfunction group and the normal balance function group (P>0.05), while the age, course of disease and visual condition were statistically different (P<0.05). Multivariate regression analysis was used to analyze the univariate analysis. Age, duration and visual condition were independent risk factors of balance dysfunction. Conclusion Patients with Parkinson's disease have higher balance dysfunction. After intervention. The balance function can be improved obviously. Age, duration of disease and visual condition are independent risk factors of balance dysfunction, precautionary measures should be taken in accordance with relevant risk factors to reduce the balance of dysfunction.