Abstract: Objective To conduct the traditional Chinese medicine (TCM) therapy of promoting blood circulation and removing stasis in patients with endometrial polyp after hysteroscopic therapy, observe the changes of Ki-67 positive expression level in endometrium and TCM syndrome score before and after treatment, evaluate the effect of traditional Chinese medicine therapy of promoting blood circulation and removing stasis in decreasing the recurrence of endometrial polyp after hysteroscopic therapy and possible mechanism, and provides a new choice for reducing postoperative relapse rate. Methods Total 147 cases of endometrial polyp after hysteroscopic therapy met the diagnosis criteria in our hospital between June, 2015 and June, 2016 were enrolled into the study, and randomly divided into traditional Chinese medicine, western medicine group and control group. The traditional Chinese medicine group received the traditional Chinese medicine therapy of promoting blood circulation and removing stasis(oral Chinese medicine and external treatment); the western medicine group received oral administration of Marvelon; the control group did not receive any treatment. Before and after the treatment, quantification of TCM syndrome score table was used to assess the TCM syndrome scores, the immunohistochemical method was used to test the expression of Ki-67 in endometrial tissue. Results After the treatment, TCM syndrome scores of traditional Chinese medicine group was obviously lower than western medicine group and control group, the difference was statistically significant; however, there was no statistically significant difference between the western medicine group and the control group. Ki-67 positive expression decreased obviously in the Traditional Chinese medicine and western medicine group, and the difference had statistical significance as compared with the control group; the expression level of Ki-67 in the traditional Chinese medicine group was lower than that in the western medicine group, the difference was statistically significant. In the control group, the level of Ki-67 did not change obviously before and after the treatment, there was no statistically significant difference. Conclusion Traditional Chinese medicine therapy of promoting blood circulation and removing stasis can significantly reduce TCM syndrome score and Ki-67 positive expression in endometrium in patients with endometrial polyp after hysteroscopic therapy, which may be the possible mechanisms of reducing postoperative recurrence rate.