Abstract: Objective In order to study whether serum uric acid level has a certain effect on anxiety symptoms in young and middle-aged people, the changes before and after treatment were compared and the correlation was analyzed. Methods We selected 82 cases of anxiety patients from July, 2015 to January, 2017 in outpatient of our hospital. HAMA was carried out at first by professional psychological physician. Then according to score of HAMA, they were divided into 7-13 scores group (26 cases), 14-20 scores group (21 cases), 21-28 scores group (18 cases) and ≥ 29 scores group (17 cases). Drug therapy or assistant psychological therapy was applied, and serum uric acid and HAMA were tested after 1 month and 3 months of therapy. Results Serum uric acid were significantly decreased in each group after therapy (P<0.05), and which of 3 month therapy was significantly decreased than which of 1 month therapy (P<0.05). HAMA scores were significantly decreased in each group after therapy (P<0.05), and which of 3 month therapy was significantly decreased than which of 1month therapy except 7-13 group (P<0.05). And we found significantly positive relative existed between serum uric acid and HAMA scores. Coefficient of association were 0.730, 0.751 (P=0.031), 0.815 (P=0.022) and 0.728 (P=0.043) respectively of each group (all P<0.05). Conclusion We found significantly positive relation between serum uric acid and anxiety symptoms of youth and middle age patients, which may hint possible nutrition metabolism indexes including uric acid level which significantly influences the assessment of treatment effects of anxiety.