Abstract: Objective To evaluate the effect of five regular methods management model combined with humanistic nursing on serum inflammatory factors in patients with hypertensive cerebral hemorrhage and its prognostic impact. Methods A total of 46 hypertensive intracerebral hemorrhage patients who underwent cerebellar decompression in our hospital from May 1, 2014 to June 1, 2017 were selected as study subjects. The study was randomized, blinded, and controlled. According to the random number table method, they were randomly divided into two groups:A (user-friendly nursing) and B (five regular methods nursing management mode combined with humanized nursing). We selected 23 healthy people who received physical examination in our hospital at the same time as group C(healthy control group), observed the changes of the vital signs at different time after operation in A and B groups; observed the expression levels of postoperative pro-inflammatory factors in A and B groups; observed the simple mental status checklists (Minimum mental state examination, MMSE) in patients A, B, and C scores. Results The changes of related vital indexes in group B were more stable than those in group A. Serum inflammatory cytokines IL-1, IL-6, IL-10 and TNF-α were significantly elevated at 24 h after operation in group B, but the levels of IL-1, IL-6 and TNF-α were significantly lower than those in group A (P<0.05). After 24 hours, the directional ability, memory ability, recall ability, and attention calculation ability of group B patients were significantly lower than those of group C, but still higher than those of group A patients, with statistical significance (P<0.05). There was a significant negative correlation between MMSE scores and IL-1, IL-6 and TNF-α, and no correlation with IL-10. Conclusion The five regular methods nursing management combined with humanized nursing measures can improve the quality of nursing and stabilize the high expression of serum-related inflammatory factors in patients with hypertensive cerebral hemorrhage, thus having certain effects on vital signs and consciousness recovery.