Abstract: Objective To evaluate the clinical efficacy and safety of modified lauromacrogol tissue glue sandwich injection combined with esophageal varices ligation in treatment of esophagogastric varices. Methods From January, 2016 to December, 2017, 82 inpatients were enrolled in the study. 41 patients were classified as the control group from January, 2016 to December, 2016, while other 41 cases were classified as the observation group from January, 2017 to December, 2017. The observation group received the modified lauromacrogol tissue glue sandwich injection combined with esophageal varices ligation, while the control group was treated by tissue glue sandwich injection combined with esophageal varices ligation. The rate of re-bleeding, improvement of esophagogastric varices and complications were observed after the treatment. The data were analyzed by suing SPSS 21.0 statistical software. Results After the treatment, the hemostatic success rate of the observation group was higher than that in the control group, with statistical significance (χ²=4.493, P=0.034). There was no significant difference in the early re-bleeding rate (P>0.05) and in the rate of delayed re-bleeding (P>0.05). There was no statistical difference in esophageal varices and gastric fundus vein varices between the two groups (P>0.05); there was no statistical difference in the postoperative fever, post sternal pain or discomfort and the total incidence of complications between the two groups (P>0.05). Conclusion Modified lauromacrogol tissue glue sandwich injection combined with esophageal varices ligation is a relatively simple, safe and effective method for esophagogastric varicose, with some advantages. The longer term efficacy and safety need to be further evaluated by multicentre randomized controlled clinical trials and lengthening the survey cycle.