Abstract: Objective To investigate the effects of Huangqi Xianlingpi decoction combined with HXTMT syndrome in patients with high serum CRP on the coagulation effect of nephropathy, TNF-alpha and blood rheology. Methods From March, 2014 to February, 2016, in our hospital inpatient or outpatient treatment of nephrotic syndrome in patients with high blood coagulation in 78 cases, were randomly divided into 2 groups, 39 cases in each group, the control group was given prednisone, low molecular weight heparin treatment; observation group on the basis of Huangqi Xianlingpi Decoction Combined with Huoxue Tongmai tablet the treatment, were treated for 2 months for a course of treatment, compared the clinical efficacy of the two groups before and after treatment, blood rheology, CRP, NO, TNF-α, ET-1 and renal function index, and record adverse events. Results Compared with before treatment, the two groups after treatment hematocrit, erythrocyte aggregation index, whole blood viscosity, plasma viscosity decreased, serum CRP, TNF-α, ET-1, 24 h Pro, elevated serum NO, BUN, Scr levels decrease, increase the total protein level (P<0.05). Compared with the control group, the observation group after treatment hematocrit, erythrocyte aggregation index, whole blood viscosity, plasma viscosity, low serum CRP, TNF-alpha, low ET-1, high serum NO, 24 h Pro, BUN, Scr level is low, the total protein levels were higher (P<0.05). The control group had no difference with the observation of non-performing rate of 17.95% group 23.08% non-performing rate comparison (P>0.05). Conclusion Huangqi Xianlingpi decoction combined with Huoxue Tongmai Tablet on blood coagulation in patients with nephrotic syndrome with high curative effect, and no increase in adverse reactions, and reduce CRP, TNF-α, improve endothelial and blood rheology.