Abstract: Objective To manage the patients with chronic heart failure (CHF) through combining the multiple self-check parameters of body weight, 6-minute walk test (6-MWT), resting heart rate (RHR), plasma brain natriuretic peptide (BNP), evaluate the effect of combined multiple self-check parameters on cardiac function status, re-hospitalization, the prognosis of patients, and discuss the correlations between the parameters. Methods Total 207 patients with CHF of New York Heart Association (NYHA) cardiac function grade Ⅱ-Ⅳ in Pudong hospital from February, 2015 to April, 2016 were recruited. The patients were randomly divided into the special messenger follow-up management group (manage group) and routine follow-up visit group (control group) according to the date of discharged from hospital after the patient's state was improved by treatment. All patients were followed up for 12 months. The body weight, systolic blood pressure (SBP), diastolic blood pressure (DBP), peripheral white blood cell (WBC), hemoglobin (HB), platelet (PLT) count, fasting plasma glucose (FPG), alanine transaminase (ALT), total bilirubin (TBIL), serum creatinine (SCr), potassium (K⁺), natrium (Na⁺), chlorine (Cl^-), BNP, NYHA cardiac function grade, left ventricular ejection fraction (LVEF), 6-MWT, sleep heart rate (SHR) and morning RHR were recorded. Results ① After one year follow-up, the body weight, BNP, SHR and RHR of the manage group patients were significantly lower than those in the control, the LVEF and 6-MWT were significantly higher than those in the control (P<0.05), the SCr, K⁺, Na⁺, Cl^- and NYHA cardiac function grade were not different statistically between the two groups (P>0.05). ② The re-hospitalization, mean hospitalization day and death after one year follow-up between the groups were different statistically (P<0.05). ③ There were good correlations between the multiple self-check parameters of body weight, 6-MWT, RHR, BNP and LVEF (P<0.05). Conclusion The program of combining multiple self-check parameters to manage the patients with chronic heart failure all-the-way can improve the patient's cardiac function status, reduce hospital readmission and hospitalization day, decrease mortality, reduce the consumption of medical resources effectively, and had significantly medical and social effects.