Abstract: Objective To explore the efficacy of asarone injection combined with bronchoalveolar lavage for refractory mycoplasma pneumonia (RMPP) in children, thus to provide reference for optimizing treatment. Methods A total of 86 cases of RMPP children from January, 2015 to January, 2016 in our hospital were divided into the control group (n=43) and the treatment group (n=43) by a randomized way. The children were given regular treatments including anti-infection and spasmolysis. The control group was given bronchoalveolar lavage; the treatment group was given asarone injection on the basis of control group. The clinic effects of two groups were compared. Before and after the treatment, the levels of PaCO₂, PaO₂, pH, CRP, ESR and classification of neutrophils were detected in the two groups. The release time of lung shadow, high fever, cough and lung sound in the two groups were observed. The rates of complication and adverse action were observed. Results In the treatment group, the total effective rate was 90.7%, significantly higher than 69.8% in the control group (P<0.05). The levels of PaO₂ and PH were (73.64±7.74) mm Hg and (7.35±0.15) in the treatment group, significantly higher than that in the control group (P<0.05), while the level of PaCO₂, CRP, ESR and classification of neutrophils were (49.45±6.78) mm Hg, (23.38±3.36) mg/L, (32.87±4.62) mm/h and (43.62±6.72)%, significantly lower than the control group (P<0.05). The release time of symptom were significantly shorter in the treatment group than which in the control group (P<0.05). There were no serious complication and adverse actions occurred in the patients. Conclusion The effect of asarone injection combined with bronchoalveolar lavage for RMPP in children is affirmative and worth to the next research.