Abstract: Objective To observe the clinical effect of combination of traditional Chinese and Western medicine in the treatment of early cesarean scar pregnancy. Methods A total of 148 cases of early cesarean scar pregnancy were as research object whom received treatment in our hospital from September, 2015 to September, 2017, all the patients were divided into the control group (n=74) and the research group (n=74). The control group were given western medicine treatment. The study group were given combination of traditional Chinese and Western medicine. The efficacy of drug conservative treatment in two groups was statistically analyzed. The serum β-hCG levels at different times were compared between the two groups. The hospitalization time and symptom relief time were recorded, and the adverse drug reactions during treatment were observed. Results The success rate of embryo treatment (78.38%) and the total success rate of conservative treatment (95.95%) in the study group were significantly higher than those in the control group (52.70% and 85.14%, χ²=10.800, 5.049; P=0.001, 0.025). After the treatment of 7, 14 and 28 d, the level of serum β-hCG in the patients of the study group was significantly lower than that of the control group (P<0.05). The time of β-hCG level arrival, the time of abnormal echo disappearance, and the time of disappearance of gestational sac in the study group were significantly shorter than those in the control group (P<0.05). The incidence of adverse reactions in the study group (13.51%) was significantly lower than that in the control group (28.38%, χ²=4.937, P=0.026). Conclusion Combined therapy of gestational sac puncture injection of methotrexate + mifepristone combined embryocide Xiaozheng decoction of traditional Chinese medicine and Western medicine, can significantly reduce the early cesarean scar pregnancy with β-hCG secretion, improve the success rate of conservative treatment, shorten the recovery period, reduce adverse drug reactions during the treatment period.