Clinical observation on 38 cases of postmenopausal osteoporosis treated with Jinggu Bugu granule
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摘要: 目的 前期实验研究证实了精骨补骨颗粒对地塞米松诱导骨质疏松模型大鼠的治疗作用,为验证该药的临床价值,进一步观察精骨补骨颗粒对于绝经后骨质疏松症(PMOP)的临床疗效。 方法 收集2016年5月-2017年4月于蚌埠医学院第二附属医院中医科就诊的80例肝肾阴虚型PMOP患者,在患者知情同意的情况下,随机分为对照组(基础治疗组)和观察组(精骨补骨颗粒组),每组40例,2组患者年龄、病程等一般资料差异无统计学意义(均P>0.05),可作为对照观察。2组均给予骨化三醇0.50 μg/d,分2次口服,观察组同时予"精骨补骨颗粒"每日一剂口服,共治疗6个月。目测疼痛分数法观察骨痛积分,以双能X线骨密度仪测定骨密度,化学发光法测量雌二醇,记录2组患者治疗后的数值变化,并记录中医证候积分以判定证候疗效。采用SPSS 23.0统计软件包建立统计数据库,分析数据,得出结果。 结果 对照组脱落1例,观察组脱落2例。2组患者骨痛积分均明显下降,骨密度数值均明显上升,观察组38例骨痛积分、骨密度数值均明显优于对照组(均P<0.001),观察组雌二醇较治疗前明显提高(P<0.001),对照组雌二醇改善不明显;在改善中医证候疗效方面,观察组总有效率为94.7%,对照组总有效率为74.4%,2组疗效比较差异具有统计学意义(P<0.05)。 结论 精骨补骨颗粒对肝肾阴虚型绝经后骨质疏松症有良效。Abstract: Objective Previous experimental studies have confirmed the therapeutic effect of Jinggu Bugu granule on dexamethasone-induced osteoporosis in rats. The study aims to verify the clinical value of the drug, and observe the clinical effect of Jinggu Bugu granule on postmenopausal osteoporosis. Methods A total of 80 patients with postmenopausal osteoporosis were collected from May, 2016 to April, 2017 in the Department of traditional Chinese Medicine of the second affiliated Hospital of Bengbu Medical College. With the informed consent of the patients,they were randomly divided into control group (40 patients in basic treatment group) and observation group (40 patients in Jinggu Bugu granule group). There was no statistical difference in the age and course of the two groups. Both groups were given 0.50 μg/d of oscitictriol in two doses. The observation group was treated with Jinggu Bugu granule once a day for 6 months. Bone pain score was observed by visual method, bone mineral density was measured by BMD and estradiol was measured by chemiluminescence. The changes in the values of the two groups were recorded and the traditional Chinese medicine score was recorded to judge the curative effect. We used SPSS 23.0 software to carry on statistics. Results One case was lost in the control group and 2 cases in the observation group. In both groups, the bone pain score decreased and the bone mineral density increased significantly. The bone pain score and bone mineral density in the observation group were significantly better than those in the control group (P<0.001). The estradiol in the observation group was significantly higher than that before the treatment (P<0.001), but the improvement of estradiol was not obvious in the control group. In improving the curative effect of TCM syndromes, the total effective rate of Jinggu Bugu granule group was 94.7% and that of the basic treatment group was 74.4%. The difference between the two groups was statistically significant (P<0.05). Conclusion Jinggu Bugu granule has good therapeutic effect on postmenopausal osteoporosis of liver and kidney yin deficiency type.
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