Abstract: Objective To analyze the application of acupoint acupuncture therapy on recurrent trigeminal neuralgia accompanied by anxiety and depression patients, and to provide reference for clinical treatment of the recurrent trigeminal neuralgia accompanied by anxiety and depression. Methods A total of 84 patients with recurrent trigeminal neuralgia accompanied by anxiety and depression who were diagnosed and inclusion criteria in our hospital were selected from February, 2015 to September, 2017, and they were randomly divided into observation group (n=42) and control group (n=42) according to the random number table method. The control group was treated with traditional Chinese medicine, and the observation group was treated with acupoint acupuncture therapy based on the control group. The clinical effect, pain degree, vasoactive intestinal peptide level, anxiety and depression score and adverse reaction rate were compared between the two groups. Results The total effective rate of clinical treatment in observation group was significantly better than that of the control group (P<0.05). Before treatment, there were no significant differences in the score of visual analogue scale (VAS) and the level of vasoactive intestinal peptide between the two groups (P>0.05). After treatment, the score of VAS and the level of vasoactive intestinal peptide were significantly lower than those before treatment (P<0.05), and the observation group was significantly lower than the control group (P<0.05). Before treatment, there were no significantly differences in the score of hamilton anxiety scale (HAMA) and Hamilton depression scale (HAMD), P>0.05. After treatment, the score of HAMA and HAMD were significantly lower than those before treatment (P<0.05), and the observation group was significantly lower than the control group (P<0.05). There was no significant difference in adverse reactions rate between the two groups (P>0.05). Conclusion The acupoint acupuncture therapy can obviously improve the degree of pain, anxiety and depression on recurrent trigeminal neuralgia accompanied by anxiety and depression patients, clinical curative effect is remarkable and adverse reaction is rare, which has high clinical application value.