Abstract: Objective To explore the effect of TCM acupuncture therapy in combination with exercise rehabilitation on the recovery of limb motor dysfunction in patients with hemiplegia caused by cerebral ischemic stroke (CIS), and to provide new ideas for improving the clinical curative effect of this disease. Methods Total 80 cases of limb motor dysfunction caused by CIS in our hospital between January, 2015 and January, 2017 were enrolled and divided into acupuncture combined rehabilitation group (40 cases) and rehabilitation control group (n=40). The curative efficacy was observed after two courses. All patients were evaluated by FMA scale and Berg balance before and after treatment, and the serum levels of Hcy were measured. The randomized controlled clinical research methods were employed in this study, and SPSS 17.0 statistical analysis software package was used for statistical analysis of the data, P<0.05 was statistically significant. Results Before the treatment, the statistical analysis showed that there was no significant difference in the general data, FMA and Berg score, and Hcy level (P>0.05). After the treatment, FMA and Berg score were improved in both groups (P<0.05), and more obvious in the acupuncture combined rehabilitation group. The Hcy level of the acupuncture combined with rehabilitation group was significantly higher than that of the control group. The total effective rates were 92.5% in the acupuncture combined rehabilitation group and 75.0% in the control group. Conclusion TCM acupuncture therapy combined with exercise rehabilitation for ischemic stroke hemiplegia patients was safe, reliable, cost-effective, and worthy of more clinical application.