Abstract: Objective To investigate the clinical value of Xiangsha Liujunzi Decoction combined with proton pump inhibitors in the treatment of elderly peptic ulcer with weak spleen and stomach. Methods A total of 112 elderly patients with peptic ulcer with spleen and stomach admitted from September, 2015 to December, 2017 were selected as study subjects. Randomized digital table was used to divide the control group with 56 cases and observation group with 56 cases. Basic treatment was performed in both groups. The control group received proton pump inhibitor treatment. The observation group was treated with Xiangsha Liujunzi Decoction on the basis of the control group. The treatment effects, disappearance of clinical symptoms, and occurrence of adverse reactions were observed in both groups. Results After treatment, the total effective rate in the observation group reached 94.64%, and the total effective rate in the control group was 82.14%. The observation group was significantly higher, and the difference was statistically significant (P<0.05).After treatment in the observation group, the disappearance time of symptoms of abdominal pain, acid reflux, hernia and epigastric cauterization was significantly shorter than that of the control group,[(3.01±0.48) vs. (4.22±0.53); (4.54±0.51) vs. (5.89±0.57); (5.12±0.63) vs. (6.34±0.69); (3.98±0.49) vs. (4.93±0.56)] and the difference was statistically significant (P<0.05); The incidence of adverse reactions was 10.71% in the observation group and 16.07% in the control group. There was no significant difference between the two groups (P>0.05), and no serious adverse reactions were observed. Conclusion In the treatment of elderly peptic ulcer with weak spleen and stomach, the application of Xiangsha Liujunzi Decoction combined with proton pump inhibitors can obtain the exact curative effect, promote the elimination of the symptoms of patients, and have high safety, and it is worthy of promotion.