Abstract: Objective To develop the basic clinical skills simulation training and knowledge intensive education precise course for general practitioners(GP), so as to improve their job competency. Methods The methods of expert interview, literature review and questionnaire survey were adopted. The 20 participants were interviewed according to the theory of knowledge group, single skill group, clinical thinking ability and attitude group and 99 GP students were investigated. According to the views of the expert group and characteristics and training needs of GP, we developed training curriculum system accurately. Results The results of 20 experts at 2/3 frequency on the course classification opinions are four categories:GP theories, individual skills, diagnosis and management of common community diseases and chronic diseases (clinical thinking), humanities and medical ethics regulations. General training requirements of the GP students:students think the main purpose of the training is to improve the clinical competency; clinical skills are the most needed knowledge and skills; video and teaching combined with practice is the preferred way of training; the most favorite humanity course is the doctor-patient communication. The projects which reach 2/3 frequency focused on the clinical skills and clinical thinking in common, which mainly include:basic diagnostic skills, basic puncture surgery, basic skills in surgery, gynecology, obstetrics, pediatrics, critical care rescue and nursing, clinical thinking and comprehensive knowledge etc. According to the survey results, a standard curriculum targeting at GP trainees was made with clear orientation. The system contains three levels involving knowledge, skills and attitudes. It concerned internal medicine, surgery, gynecology, pediatrics, emergency treatment, nursing, general clinical thinking and the related theory. Conclusion The curriculum system promotes the competency of general practitioners, and achieves the standardization, normalization and homogenization of clinical basic skills.