Abstract: Objective To summarize and analyze the influence of nutrition and social support on the quality of life in patients with colorectal cancer. Methods In our hospital from January, 2012 to January, 2015, 128 cases of patients with advanced colorectal cancer were chosen as the research object, whose clinical data were analyzed, the relationship between nutritional status during chemotherapy, social support, quality of life (physical function, emotional function, role function, cognitive function, social function and the secondary reaction was summarized. Results ① The nutritional status score, the score of subjective support and social support scores in the group under 60 were higher than those 60 years old or above. The nutritional status score, the score of objective support, subjective support and support availability score and total score of social support were higher in male group than those in the female group. The nutritional status score, the score of subjective support and support availability of social support score and total score were higher in radical surgery group than in palliative group. The nutritional status of patients with chemotherapy group was lower than those without chemotherapy, while the total score of social support in group with chemotherapy was higher than that in the non-chemotherapy group, with statistical significance (P<0.05). ② And 25.78% scores 15 or more in the nutritional quality of life, which was significantly higher than those less than 15 scores (P<0.05); social support evaluation above 40 group whose life quality was assessed as good accounted for 27.34%, significantly higher than scores less than 40 (P<0.05). Conclusion The nutritional status of patients with colorectal cancer and the status of social support will directly affect the quality of life, improve the nutrition and improve social support, and improve their quality of life. For the elderly, retirement, chemotherapy, advanced patients, social support is very important to raise awareness of clinical treatment and nursing care.