Abstract: Objective To investigate the relationship between different emotional labor strategies and burnout in cardiovascular nurses and to explore the regulating effect of self-compassion on two kinds of emotional labor strategies and burnout. Methods From October, 2016 to January, 2017,154 nurses in Guangzhou were invited to complete the questionnaires in paper. It includes basic demographic information, emotional labor strategy scale, Chinese Maxlach Burnout Inventory and self-compassion scale. Finally, the data were entered and analyzed by statistics. Results ①Surface acting in emotional labor strategy has a significant positive influence on burnout(r=0.404, P<0.001). Meanwhile, deep acting(r=-0.345, P<0.001) and self-compassion(r=-0.356, P<0.001) are negatively correlated with burnout. ②There is a significant positive correlation between deep acting and self-compassion(r=0.340, P<0.001). There is no significant correlation between surface acting and self-compassion, but the direction is negatively correlated(r=-0.083). ③Self-compassion is found to play a regulating role on surface acting and burnout, as well as an intervention role on deep acting and burnout. Self-compassion has no moderating effect on the relationship between deep acting and burnout. Conclusion Nurses with high self-compassion prefer deep acting, followed with lower burnout. For whom choosing surface acting, highly self-compassion can reduce their burnout. Besides, high self-compassion can significantly alleviate burnout. Thus, an effective way to reduce the level of nurses' burnout is by guiding nurses to use deep acting to regulate emotions and improve their self-compassion level.