Abstract: Objective To observe the diagnostic value of transvaginal ultrasonography in early pregnancy abortion. Methods A total of 500 cases of early pregnancy women who were admitted to our hospital and underwent prenatal examination in our hospital were selected as research subjects. The transvaginal color Doppler ultrasound, corpus luteum morphology, blood flow and ultrasound echo were detected, the outcome of early pregnancy were tracked, and the size, character, ultrasonic echo, PSV and RI of corpus luteum flow were observed between the normal pregnancy, the threatened abortion and the unavoidable abortion. Results The overall incidence of threatened abortion was 22.60%; The corpus luteum in normal early pregnancy was thick walled and round, while the percentage of rods and spots in corpus luteum was the highest among the 3 groups (35.71% and 21.43%). The echo of corpus luteum in normal early pregnancy group was the main type of strong echo (84.50%), but the incidence of luteal inhomogeneous hypoechoic in the abortion group was the highest (52.28%), and the abnormal rate of corpus luteum (26.76%) in the threatened abortion group was significantly lower than that of the free abortion group (83.33%, χ²=33.850,P<0.001). The PSV value of luteal blood flow in normal early pregnancy group and threatened abortion continued pregnancy group was significantly higher than that in inevitable abortion group (P<0.05), and the RI values of luteal blood flow were significantly lower than those of patients with inevitable abortion (P<0.05), the luteal flow rate in the normal early pregnancy group and the threatened abortion group (100.00% and 88.72%) were significantly higher than those in the free abortion group (71.43%, P<0.05). Conclusion There are significant changes in the morphology and blood flow status of the corpus luteum in early pregnancy abortion patients, and there are also significant differences between the patients with early pregnancy abortion with different pregnancy outcomes. The diagnosis of early pregnancy abortion by transvaginal ultrasound is of certain value in the diagnosis of early pregnancy abortion.