Abstract: Objective To describe the level and influence factors of self-perceived burden among hospitalized stoma patients after operation and analyze the correlation of self-efficacy and quality of life and it's influencing factors. Methods This is a descriptive correlational study. From January, 2016 to June, 2017, 151 stoma hospitalized patients were invited to complete demographic questionnaire, self-perceived burden (SPB) scale, and strategies used by people to promote health and stoma quality of life scale. General data of stoma patients were described by mean standard deviation and frequency. Univariate analysis was done by t-test and ANOVA. The relationship of SPB, self-efficacy and quality of life was assessed by Pearson correlation analysis. Statistically significant variables were introduced into the regression model as independent variables for multiple linear regression analysis. Results All of the patients got the average score (39.64±8.83) on SPB scale, among moderate level, with 50.3% patients among high level. The self-efficacy and quality of life have a negative relationship with SPB, and the correlation coefficient was -0.441 and -0.459 respectively. The influencing factors of SPB of stoma hospitalized patients include educational level, stool leak and stink rate and self-efficacy. Conclusion Stoma patients have serious level of self-perceived burden. Nurses should encourage patients to face difficulties and challenges, learn stoma care skills and communicate with others actively. Besides, stoma patients who have lower educational level should be taken into consideration.