Abstract: Objective To investigate the effects of comfort care in operation room on postoperative analgesia and satisfaction of patients with intercostal nerve block combined with controlled analgesia. Methods From January, 2013 to February, 2017, 140 cases of breast cancer patients in our hospital were selected as the subjects, and all the patients were randomly divided the observation group and control group with 70 cases in each group. All patients were given intercostal nerve block combined with controlled analgesia, the control group received routine nursing in operation room, and the observation group was given comfortable nursing in operation room nursing based on the control group. We recorded anesthesia, pain, quality of life and satisfaction of nursing care of the two groups. Results All the patients successfully completed anesthesia block without serious complications. The analgesia onset time, perfect time compared between the two groups were not significantly different (P>0.05). The immediate and postoperative pain scores in the observation group were (1.55±0.45) points and (0.56±0.55) points which were significantly lower than (2.76±1.22) points and (1.43±0.82) points of the control group (P<0.05). The postoperative satisfaction degree in the observation group and the control group were 100.0% and 88.6% respectively, and the observation group was better than that of the control group (P<0.05). After 6 months follow-up, the scores of psychological health, mental health, physical pain and social support in the observation group were significantly higher than those of the control group (P<0.05). Conclusion There is a good anesthetic effect of intercostal nerve block combined with controlled analgesia in patients with breast cancer. Application of comfort care in the operation room can enhance the analgesic effect, improve the nurse patient relationship, and promote the survival quality.