Abstract: Objective To investigate the effect of high-dose gamma globulin combined aspirin on vascular endothelial factor,resistin and visfatin of children with Kawasaki disease and observe its clinical efficacy. Methods A total of 62 patients with Kawasaki disease in Hangzhou First People's Hospital from January, 2015 to December, 2016 were selected as the observation group and treated with large doses of gamma globulin and aspirin.High-dose gamma globulin was 2 g/(kg·d),intravenous injection,and aspirin enteric-coated tablets. 30-50 mg/(kg·d) was given orally 3 times,reduced to 3-5 mg/(kg·d) 3 days after antipyretic therapy,and administered orally once a day for 2 months. Another 62 healthy children who had physical examination in our hospital during the same period were selected as the control group.Before and after treatment,the levels of inflammatory factors (hs-CRP, TNF-α) and vascular endothelium-related markers (VEGF, eNOS, ES) were measured by enzyme-linked immunosorbent assay, PCT levels were measured by double-antibody sandwich assay, resistin and visfatin levels were measured by double-antibody enzyme-linked immunosorbent assay. The therapeutic effect was compared with the control group. Results After treatment,the PCT, hs-CRP and TNF-α levels of observation group were significantly reduced (P<0.05). After treatment, VEGF, ES, resistin and visfatin levels of observation group were significantly decreased (P<0.05), and the eNOS level was significantly increased (P<0.05). The total effective rate of treatment was 91.93%. Conclusion High-dose gamma globulin combined with aspirin can significantly reduce the inflammatory response of children with Kawasaki disease and reduce vascular endothelial injury. The mechanism may be related to the large dose of gamma globulin combined with aspirin can effectively regulate the resistin and visfatin in children.