Abstract: Objective Via an outpatient chemotherapy model supported by hospital information system, taking into account patient safety and satisfaction effectively release the resources of the ward and the day medical department, to solve the problem of long patient hospital stay, cumbersome hospital admission procedures, etc., on the premise of safety and patient satisfaction, chemotherapy patients in inpatient wards and day medical wards are gradually transferred to outpatient clinics to further regulate the limited hospital bed resources so as to meet the hospitalization needs of more surgical and critically ill patients, resulting in "major surgery in the inpatient, minor operations in the day ward, and micro-surgery in the outpatient", and then explore the importance of establishing safe outpatient chemotherapy to improve the efficiency of hospital services, optimize the supply of medical resources, and strengthen the service orientation of tertiary comprehensive hospitals. Methods This article analyzes the effect and significance of outpatient chemotherapy in four dimensions:total cost of treatment, time of hospitalization, cost of medical resources, and patient satisfaction through the gradual transfer of chemotherapy patients from inpatient wards to daytime medical wards to outpatient clinics. Results The development of outpatient chemotherapy can shorten the patient's hospital stay, reduce the patient's medical expenses, and improve the patient's satisfaction. It can help improve the hospital's service efficiency, optimize the supply of medical resources, and help strengthen the three-level comprehensive hospital's medical service positioning. Conclusion Outpatient chemotherapy not only provides safe, comfortable, convenient and economical treatment for patients, but also saves limited medical resources and reduces treatment costs. It is a medical model worthy of being widely promoted, which improves the efficiency of hospital services and optimizes medical resources. The supply and strengthening of the three-level comprehensive hospital service positioning have certain significance.